The dream of bringing the T. rex as shown in so many movies, the most recent one being Jurassic World captures everyone’s imagination. The movie Jurassic World along with its predecessors, many zombie and vampire movies all talk about gene splicing and adding a trait from one species to another. You can imagine what many molecular cell biologists, geneticists and many other individuals involved in research using cutting edge technologies groan when they see the term used liberally. It lulls the avid movie fan who may not have exposure to the difficulties and advancements in gene splicing technologies into a false impression that mixing DNA between species and getting a fully functional organism is easy.
In the world of gene splicing, the term that is driving all the researchers wild just as the new Halo 5 due to be released in November 2015 is going to drive all the gamers wild, is CRISPR-CAS9. Researchers are now able to actually edit DNA and insert with some restrictions pieces of DNA that gives them the trait or molecular effect they are looking for in a cell. Needless to say that, despite technical restrictions like the size of the gene insert and type of cell line used, it has given researchers a more precise cutting tool than PCR which for its time was the major advancement.
Well, in a nature news update today, CRISPR has just got crispier if I might use the term. Scientists have found a smaller size version of the CAS9 enzyme which makes it easier to insert bigger pieces of DNA into a plasmid.
Check out what Zhang and his team at the BROAD institute have found in this latest Nature update.
Happy Gene cutting everyone.